So here is my advice on how to get max streaming performance from MED1000X3D and probably other Mede8er models too.
Use NFS protocol with options set to UDP and rsize set to 32K (32768). Be sure NOT to use jumbo frames (large MTU).
Obviously use Gigabit network.
I use drobo 5N as one of my NAS boxes and have successfully got it working for high bit rate content (remuxed Blu-ray content to MKV).
NFS is not available on drobo 5N by default, but you can add this service via 3rd party App.
Take a look in this thread: http://www.drobospace.com/forums/showthread.php?tid=103534
UDP takes less CPU/network power than TCP and therefore it is better for streaming in LAN.
MTU size is not negotiated via UDP and if MTU sizes does not match between server (NAS) and player, then data transmission will not work. That is why Jumbo frames must be disabled so default MTU sizes are used on both ends.